DAILY CURRENT AFFAIRS IAS | UPSC Prelims and Mains Exam –20th June 2023
Archives (PRELIMS & MAINS Focus) Sickle Cell Anaemia Disease Syllabus Prelims – Science and Technology Context: Recently, a workshop to educate people about Sickle Cell Anaemia Disease was held in New Delhi. About Sickle Cell Anaemia Disease:- IMAGE SOURCE: SlideServe Discovery: in 1910 by James Herrick. Sickle cell anaemia is a group of inherited disorders known as sickle cell disease.(UPSC CSE: Rare Diseases) It affects the shape of red blood cells. Red blood cells: contain haemoglobin, which carries oxygen to all parts of the body. Cause: It is transmitted by parents carrying a defective ‘beta globin’ gene. Disease condition: under normal conditions, the red blood cells being round and flexible move easily through blood vessels. However, in sickle cell anaemia, some of the red blood cells acquire the shape of sickles or crescent moons. These sickle cells become rigid and sticky. When they travel through small blood vessels, they get stuck and clog the blood flow. This can cause pain and other serious health problems such as infection, acute chest syndrome and stroke. . (UPSC CSE: Polio Disease) The sickle cells also die early, which causes a constant shortage of red blood cells. Symptoms:- Chronic Anaemia: leading to fatigue, weakness, and paleness. Painful episodes (also known as sickle cell crisis): these can cause sudden and intense pain in the bones, chest, back, arms, and legs. Delayed growth and puberty. Mortality rate:- Mortality rate refers to the percentage of people with a condition who died within a certain period. Sickle cell disease mortality burden is highest in children. However, the mortality rate of SCA for children has dropped dramatically over the last few decades. A 1975 study indicated a mortality rate of 9.3 per cent for people with SCA under the age of 23. However, by 1989, the mortality rate for people with SCA under the age of 20 dropped to 2.6 per cent. Treatment:- Blood Transfusions: These can help relieve anaemia and reduce the risk of pain crises. Hydroxyurea: This is a medication that can help reduce the frequency of painful episodes and prevent some of the long-term complications of the disease. It can also be treated by bone marrow or stem cell transplantation. Bone marrow transplant: a medical treatment that replaces the bone marrow with healthy cells. It can be used to treat certain types of cancer, such as leukaemia, myeloma, and lymphoma, and other blood and immune system diseases that affect the bone marrow. Government initiatives:- Ministry of Tribal Affairs: launched a portal wherein people can register themselves, in order to collate all information related to SCA among tribal groups. National Health Mission guideline on Hemoglobinopathies: it also identifies “establishing services at the community level for pre-marital and pre-conception screening backed by genetic counselling services” as a strategy for addressing SCA. Government released technical operational guidelines: for the prevention and control of hemoglobinopathies in 2016 including sickle cell anaemia. Integrated centres: have been established in 22 tribal districts for treatment and diagnosis. State Haemoglobinopathy Mission: established in Madhya Pradesh to address the challenges in screening and management of the disease. Union Budget 2023-24: the government has announced a mission to eliminate Sickle cell Anemia by 2047. Under this universal screening of seven crore people in the age group of 0-40 years in affected tribal areas would be done through collaborative efforts of central ministries and state governments. MUST READ: Disease Surveillance System SOURCE: AIR PREVIOUS YEAR QUESTIONS Q.1) In the context of hereditary diseases, consider the following statements: (2021) Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of the egg. A child inherits mitochondrial diseases entirely from the mother and not from the father. Which of the statements given above is/are correct? 1 only 2 only Both 1 and 2 Neither 1 nor 2 Q.2) Consider the following statements: Adenoviruses have single-stranded DNA genomes whereas retroviruses have double-stranded DNA genomes. Common cold is sometimes caused by an adenovirus whereas AIDS is caused by a retrovirus. Which of the statements given above is/are correct? 1 only 2 only Both 1 and 2 Neither 1 nor 2 Ketoprofen and Aceclofenac Syllabus Prelims –Science and Technology Context: Recently, the Drugs Technical Advisory Board (DTAB), recommended banning the manufacture, sale and distribution of Ketoprofen and Aceclofenac. About Aceclofenac:- IMAGE SOURCE: SlideShare Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID). NSAID: medications used for reducing pain (analgesic), decreasing fever (antipyretic), preventing blood clots (anti-thrombotic) and decreasing inflammation (anti-inflammatory). Uses: to treat non-inflammatory conditions such as migraine, period pain and postoperative pain, and to reduce fever. Common NSAIDs: aspirin (such as Disprin), ibuprofen (such as Nurofen) , naproxen (such as Naprosyn), diclofenac (such as Voltaren), celecoxib (such as Celebrex). Aceclofenac has anti-inflammatory and analgesic properties. Analgesic: medicines used to reduce pain. Anti-inflammatory: medicines used to decrease inflammation. Working Mechanism: Aceclofenac works by preventing the release of a chemical substance that causes pain and swelling in your body. Uses- It is used in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It provides relief from pain, stiffness, and swelling due to various conditions related to the bone and joints. It is also used to provide relief from headaches, toothaches, backaches, menstrual pain, sprains, and strains. Side effects: dizziness, nausea, vomiting, heartburn, stomach pain, indigestion, and diarrhoea. Ketoprofen Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain or inflammation caused by arthritis. Other Uses:- It is used to relieve pain, tenderness, swelling and stiffness in conditions such as osteoarthritis and rheumatoid arthritis. It is also used to relieve minor aches and pains from headaches, menstrual periods, toothaches, the common cold, fever, muscle aches, backaches, etc. Side effects:- Indigestion, Dizziness, Headache, Nausea, Diarrhea, Rash, Abdominal pain etc. Drugs Technical Advisory Board (DTAB) DTAB is a statutory body under the Drugs and Cosmetics Act, 1940. It is the highest decision-making body on technical matters related to drugs in the country. It is part of the Central Drugs Standard Control Organization (CDSCO)
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