DAILY CURRENT AFFAIRS IAS | UPSC Prelims and Mains Exam – 8th March 2024
Archives (PRELIMS & MAINS Focus) Biosimilars Syllabus Prelims & Mains – Science Context: Clinical trials are being conducted by an Indian pharmaceutical company to test a biosimilar of Pertuzumab (drug for treatment of breast cancer) that was invented by swiss company Roche. Background:- Since Comparator clinical trials have to be conducted in comparison to a “reference product”, which in this case is Roche’s product, the Indian company had to procure Roche’s products for their clincal studies.Roche, which presumably keeps close track of the sales of its drugs (which are expensive and subject to stringent storage protocols) has now raised questions on how and where the Indian company accessed the “reference products” for the purpose of its clinical trials. About Biosimilars:- Biosimilars are similar copies of a class of drugs called biologicals. Biological medicines have created new opportunities to treat diseases, including cancers, autoimmune conditions and diabetes, to name a few. As their name suggests, biologics are made with biological materials, including materials from humans, plants, animals, bacteria, and other microorganisms; they go through a rigorous, tightly controlled manufacturing process and tend to be patented. Biologics are highly complex molecules that are grown rather than synthesized and have an inherent level of micro-variability. Because of this variability in the structure of reference biologics, biosimilars cannot be exact copies. Instead, biosimilars mimic the active ingredient in the reference biologic. A biosimilar has a structure that is highly similar to, but not exactly the same, as a brand name biologic. A biosimilar behaves in much the same way, so that there are “no meaningful differences” between it and its brand name biologic. This means that the biosimilar is also considered as safe and effective as the biologic. Biosimilars vs. Generic Medications Biosimilars are often compared to generic medications, but there are key differences. The active ingredient within generic versions (of drugs that aren’t biologics) are exact copies of name brand medications, made with an easily repeatable manufacturing process. In contrast, due to the variability of biologics, biosimilars cannot be exact copies but they do have the same mechanism of action and the same expected benefits and risks as the original biologics. Similar to generics, biosimilars provide patients with lower-cost medicines, often making these treatments more accessible and improving quality of life for patients. Source: Scroll Women in constituent assembly of India Syllabus Prelims -History Context: Remembering the stories of women leaders on Women’s Day Background: Even after seven decades of Independence, the gendered writing of our history and popular narratives present only men as the architects of our Constitution. However, the 299-member Constituent Assembly had a bright set of 15 women who came from diverse backgrounds and endured patriarchy, caste oppression, child marriage and widowhood. Women in constituent assembly of India : The women members of the Constituent Assembly were Ammu Swaminathan, Dakshayani Velayudhan, Begum Aizaz Rasul, Durgabai Deshmukh, Hansa Mehta, Kamla Chaudhary, Leela Roy, Malati Choudhury, Purnima Banerjee, Rajkumari Amrit Kaur, Renuka Ray, Sarojini Naidu, Sucheta Kriplani, Vijaya Lakshmi Pandit and Annie Mascarene. Annie Mascarene:She fought to integrate the princely state of Travancore into the newly independent India and became the first woman to hold a ministerial and legislative assembly position in Travancore(erstwhile princely state; part of Kerala after its formation). Hansa Jivraj Mehta:She remained committed to women’s issues throughout her life and, in the Constituent Assembly, made strong arguments against reservations for women as a tool for equality and justice. Dakshayani Velayudhan:Born into the Pulaya community of Kerala, Dakshayani Velayudhan faced acute discrimination from the upper caste communities in Cochin and Travancore. Amrit Kaur:She played an important role both during the freedom struggle and in shaping independent India. Kaur joined Gandhi in the Civil Disobedience movement in 1930.Kaur also served as the first women Health Minister Ammu Swaminathan:She started becoming politically involved in 1917 when she formed the Women’s India Association along with Annie Besant to address the social and economic problems of women workers. Durgabai Deshmukh:Remembered as the ‘Mother of Social Work’, Durgabai Deshmukh was one of the drivers of rigorous nation-building and social reform.She pioneered the Andhra Mahila Sabha in 1937, which became an institution of education and social welfare. Begum Aizaz Rasul: She was the only Muslim woman member in the Constituent Assembly and advocated for minority rights in a secular state. She opposed reservations and separate electorates on communal lines. Vijaya Laxmi Pandit: She was the first woman cabinet minister in the British era and also one of the first leaders to call for an Indian constituent assembly to frame a Constitution.She was also the first woman President of the UN General Assembly in 1953. Source: Indian Express DIGITAL INTELLIGENCE PLATFORM (DIP) Syllabus Prelims : Current event Context: Recently, Union Minister for Communications launched the Digital Intelligence Platform (DIP). Background: The Department of Telecommunications (DoT) introduced two initiatives, Chakshu and the Digital Intelligence Platform (DIP), to combat spam and fraud calls through the Sanchar Saathi portal. About Digital Intelligence Platform (DIP) The Digital Intelligence Platform (DIP) is an integrated and secure platform developed by the Department of Telecommunications (DoT) in India. Its purpose is to enhance information exchange, real-time intelligence sharing, and coordination among various stakeholders. The DIP aims to curb the misuse of telecom resources in cyber-crime and financial frauds. It empowers citizens to proactively report suspected fraudulent communication through the Chakshu (चक्षु) facility on the Sanchar Saathi portal. Key Features of DIP: Case Recording and Information Sharing: The DIP records details of instances related to telecom misuse and fraud. It shares this information with relevant stakeholders, allowing them to take action within their respective domains. Backend Repository for Citizen-Initiated Requests: The DIP serves as a backend repository for requests initiated by citizens on the Sanchar Sathi portal. These requests pertain to cyber fraud or misuse of telecom resources. Stakeholders can use this repository to address cases effectively. Chakshu Platform: As part of the Sanchar Sathi portal, the government introduced the Chakshu platform. Citizens can use Chaksu to report suspected cyber or telecommunication fraud. It enhances the capability to
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