Archives (PRELIMS Focus) Nobel Prize in Medicine 2025 Category: Miscellaneous Context: The annual Nobel Week kicked off with three scientists, sharing the Nobel Prize in Medicine for unravelling tantalising aspects of the human immune system. About Nobel Prize in Medicine 2025: Awardees: The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Bruncko, Fred Ramsdell, and Shimon Sakaguchi. Awarded for: They were awarded for discovering the mechanism and key constituents of the so-called ‘peripheral immune tolerance’, a fundamental mechanism that prevents our immune system from attacking the body’s own tissues. Identification of T-cells: Their collaborative research identified Regulatory T cells (Tregs), specialized immune cells that act as “guardians” to prevent the immune system from mistakenly attacking the body’s own cells. The discovery of the Foxp3 gene revealed its crucial role in the development of Treg cells and in controlling immune tolerance. Significance: Their discovery has helped blaze new paths into treating cancer as well as auto-immune disease, a condition by which the immune system ends up harming healthy cells they are meant to protect. This may also lead to more successful transplantations. Several of these treatments are now undergoing clinical trials. Contribution of Shimon Sakaguchi: He made the first key discovery in 1995. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune cells being eliminated through a process called central tolerance. Mr. Sakaguchi showed that the immune system is more complex and discovered a previously unknown class of immune cells, which protects the body from autoimmune diseases. Contributions of Mary Brunkow and Fred Ramsdell: They made the other key discovery in 2001, when they presented the explanation for why a specific mouse strain was particularly vulnerable to autoimmune diseases. They had discovered that mice have a mutation in a gene that they named Foxp3. They also showed that mutations in the human equivalent of this gene triggered a serious autoimmune disease, IPEX. Two years after this, Mr. Sakaguchi was able to link these discoveries. He proved that the Foxp3 gene governs the development of the cells he identified in 1995. These cells, now known as ‘regulatory T cells’, monitor other immune cells and ensure that our immune system tolerates our own tissues. Source: The Hindu Lingayats Category: History and Culture Context: Karnataka Minister countered the demand for a separate religious status for Lingayats, and said that “no force can separate Veerashaivas and Lingayats” in the State. About Lingayats: Nature: Lingayats are followers of 12th-century social reformer Basavanna and his vachana (verses) philosophy, which emphasized equality, social justice, and devotion, rejecting Brahmanical authority, temple worship, and caste distinctions. Shaivite: They are a Shaivite sect in Hinduism that emerged in Karnataka during the reign of the Kalachuri dynasty. Basavanna, a minister in the court of Kalachuri King Bijjala (1157-67 CE), was the key proponent of Lingayatism. Worship of Ishtalinga: They promoted work as worship and offered spiritual enlightenment for all, including householders and artisans. Lingayats worship ishtalinga, a formless God, and reject rituals, focusing on honest labour and social redistribution. Rejected Brahmanical Authority: They prioritized direct worship of Shiva and rejected the Vedic authority, the caste system, and Brahmin ceremonies. Fostered social reforms: They encouraged post-puberty marriage, re-marriage of widows, and the promotion of inter-caste relationships. Anubhava Mantapa: Basavanna established the Anubhava Mantapa, a “Hall of Experience,” where people from all social backgrounds could gather, discuss religious and social issues, and share their experiences. Questioned theory of re-births: They bury their dead instead of cremating them (as they believe that devotees will be united with Shiva and will not return to this world). Gave importance to compassion: They stressed the importance of being a compassionate and socially productive human being in this world and in this life. Kayaka as means of worship: They considered all forms of labour and means of livelihood (kayaka) a form of worship. They provided the honest earnings from labour (kayaka), which are primarily used for social redistribution, called ‘dasoha’. Distribution: Lingayats are found primarily in Karnataka, where Lingayats comprise a major population. They are also found in significant numbers in Maharashtra and Andhra Pradesh. Difference with Veershaivas: Veerashaivism, a sect deeply rooted in the Vedas and Agamas, centres solely around the worship of Lord Shiva as mentioned in Hindu mythology. Its followers are devoted to five religious centres known as Pancha Peethas, which are established similarly to the four peethas set up by Adi Shankara. Source: The Hindu Civil Liability for Nuclear Damage Act (CLNDA), 2010 Category: Polity and Governance Context: Finance Minister said that government intends to amend Civil Liability for Nuclear Damage Act as deliberations within the government continue on bringing in new legislation to allow the private sector to operate nuclear plants in India. About Civil Liability for Nuclear Damage Act (CLNDA), 2010: Nature: It is India’s nuclear liability law ensuring compensation for victims and defining responsibility for nuclear accidents. In sync with CSC: It aligns with the Convention on Supplementary Compensation (CSC, 1997), adopted post-Chernobyl to set global minimum compensation standards. India ratified CSC in 2016. Follows global conventions: It follows the nuclear liability principles of the Vienna Convention 1963, Paris Convention 1960, and Brussels Supplementary Convention 1963. Puts a cap on operator liability: The Act imposes strict, no-fault liability on operators, caps operator liability at Rs 1,500 crore. Provision for intervention of government: If damage claims exceed Rs 1,500 crore, the CLNDA expects the government to intervene. The government’s liability is capped at the rupee equivalent of 300 million Special Drawing Rights (SDRs), roughly Rs 2,100 to Rs 2,300 crore. Nuclear Damage Claims Commission: The Act also establishes a Nuclear Damage Claims Commission to ensure fair compensation and resolve conflicts. Supplier Liability: India’s CLNDA is unique as it introduces supplier liability under Section 17(b), enabling operators to seek recourse against suppliers; unlike global frameworks like the CSC, which place liability solely on the operator. Broadens supplier responsibility: Unlike CSC, which allows recourse only for contractual breaches or intentional acts,