DAILY CURRENT AFFAIRS IAS | UPSC Prelims and Mains Exam – 22nd August 2024
Archives (PRELIMS & MAINS Focus) VACCINE-DERIVED POLIO Syllabus Prelims & Mains – SCIENCE AND TECHNOLOGY Context: A two-year-old child in Meghalaya has been infected with vaccine-derived polio. Background:- Polioviruses are enteroviruses that are transmitted primarily by the faecal-oral route. Vaccine-Derived Polio (VDPV): Vaccine-derived polio is a rare condition that occurs when the weakened (also called attenuated) strain of poliovirus used in the oral polio vaccine (OPV) mutates and regains the ability to cause paralysis. Mechanism: OPV contains a live, attenuated virus that is used for immunisation against the disease. This weakened virus triggers an immune response when administered, thus protecting people from the disease. The attenuated virus replicates in the intestines for a limited period and is excreted in the stool. In rare cases, the virus can mutate enough to cause the disease again, and circulate in areas where either immunisation is low, or where immunocompromised persons reside, or regions with poor sanitation and hygiene. Poliovirus Types: Three types – wild poliovirus type 1 (WPV1), wild poliovirus type 2 (WPV2) and wild poliovirus type 3 (WPV3). About polio vaccines The first successful polio vaccine for poliovirus was made by Jonas Salk, in the early 1950s. Salk inactivated the virus using formaldehyde and injected it into the muscles of test subjects. This inactivated polio vaccine (IPV) induced systemic immunity in the subjects. After Salk, Albert Sabin developed another vaccine that contained live polio strains, weakened by growing them serially in macaque cells, making them unfit for human infection. Since this vaccine contained the live virus, it had to be administered through its natural mode of infection – in this case, oral. This is what we today know as the OPV. OPV is usually preferred over IPV because of its ease of administration & is inexpensive. However, the weakened virus in OPV can occasionally revert, causing the disease it is meant to prevent. IPV, on the other hand, is a less potent vaccine, but contains inactivated virus particles and hence no risk of causing vaccine-associated paralytic polio (VAPP) – a rare, adverse reaction to OPV. IPV is comparatively tougher to manufacture too. Vaccine-associated paralytic polio (VAPP) or vaccine-derived poliovirus (VDPV) are similar but different phenomena. On World Polio Day, October 24, 2019, the WHO declared that WPV3 has been eradicated worldwide. WPV2 was officially declared eradicated in 2015. However, more than 90% of vaccine-derived poliovirus outbreaks are due to the type 2 virus present in oral polio vaccines. VAPP constitutes 40% of cases caused by the type 2 oral polio vaccine. Many cases of VAPP from type 3 virus too occur in countries using OPV. The Indian government does not count VAPP as polio since these cases are sporadic and pose little or no threat to others. Even after the global switch from trivalent (containing all three variants) to bivalent (type 1 and type 3) oral polio vaccines in 2016 to prevent any more type 2 vaccine-derived poliovirus, the number of vaccine-derived type 2 poliovirus outbreaks have only increased sharply. Source: Hindu INDIA AND JAPAN Syllabus Mains – GS 2 Context: India and Japan recently stated that they reaffirmed their commitment to maintaining and strengthening rules-based international order founded on the principles of the UN Charter, respect for national sovereignty and territorial integrity, and peaceful settlement of disputes. Background: This was stated in a joint statement released by both countries following the third Japan-India 2+2 Foreign and Defence Ministerial Meeting in New Delhi. Takeaways from the third Japan-India 2+2 Foreign and Defence Ministerial Meeting The India-Japan partnership is set against a larger context of a free, open and rules-based Indo-Pacific amid China’s increasing military muscle-flexing in the region. Both countries agreed to explore discussions for coordination and cooperation in the field of defence and security assistance to third countries for peace and stability in the Indo-Pacific region. The ministers welcomed the Japan Maritime Self Defense Force and Indian Naval Force exploring future cooperation in the area of ship maintenance in India. They reiterated support for ASEAN’s unity and centrality and their full support for the ‘ASEAN Outlook on the Indo-Pacific (AOIP)’ which upholds the principles such as openness, transparency, inclusivity, a rules-based framework and respect for international law. They agreed to continue working together on Security Council reform with a view to strengthening the UN. Ministers took note of the first air visit by Japanese fighters and their participation at Tarang Shakti—which is the first multilateral exercise hosted by the Indian Air Force. They also welcomed the conduct of the inaugural edition of the bilateral fighter exercise ‘Veer Guardian 2023’ between the Japan Air Self Defence Force (JASDF) and Indian Air Force (IAF) and conduct of the bilateral exercises of all the three services in one calendar year for the first time in 2023. Countries agreed to deepen bilateral cooperation in fields of space and cyber and reaffirmed the importance of multilateral defence cooperation and exchanges in the Indo-Pacific region, while expressing their commitment to continuing bilateral and multilateral exercises including Dharma Guardian, JIMEX and Malabar. The “2+2” dialogue with Japan was initiated to further deepen bilateral security and defence cooperation and bring greater depth to the special strategic and global partnership between the two countries. India has the “2+2” Ministerial format of dialogue with very few countries, including the United States, Australia, and Russia. Source: Indian Express WHEN THE LAW FAILS WOMEN Syllabus Mains – GS 2 AND GS 4 Context: Ever since the infamous gang rape that rocked the country in December 2012 (Nirbhaya), much has been done to strengthen the laws on rape. But brutal incidents of rape continuing unabated should prompt us to ask several questions regarding existing laws. Background: It is no surprise that the first accused apprehended in the Kolkata rape and murder case had a history of violent assault of his wife. Yet, there was no appropriate legal response at the time despite two complaints. Where lies the malaise & Why is the law failing to act as a sufficient deterrent? One answer is
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